PYRIDINE
PYRIDINE It is especially suitable for the dehalogenation, where it acts as the base of the elimination reaction and bonds the resulting hydrogen halide to form a pyridinium salt.
- Part number
- RXSOL-19-6605-002
- Category
- Solvent Chemicals
- Brand
- RXSOL
Overview
Pyridine Molecular Formula is C5H5N, its Hetrocyclic structure is similar to Benzene RING. Pyridine is an alkaline colorless, flammable liquid. Pyridine release unpleasant smell.
Technical specifications
| PRODUCT NAME | : | PYRIDINE |
| CAS number | : | 110-86-1 |
| UN number | : | 1282 |
| Formula | : | NC4H4CH |
| Odour | : | PUNGENT |
| Solubility in water | : | COMPLETE |
| Density | : | 0.982 at 20 oC |
| Boiling point | : | 115 oC |
| Melting point | : | -42 oC |
| Viscosity | : | 0.97 cp at 20 oC |
| Flashpoint | : | 17oC |
| Explosive limits | : | 1.7 – 10.6 Vol% |
| Vapour pressure | : | 20 mbar at 20 oC |
| Skin absorption/irritation | : | 20 mbar at 20 oC |
| TLV Country NL Year 1995 | : | 5 ppm 15 mg/m3 |
| Pollution category 1994 | : | D |
Applications
Properties: Pyridine is miscible with water It is a weak base It is highly flammable It has a distinctive, unpleasant fish-like smell
Pyridine is used as a polar, basic, low-reactive solvent, for example in Knoevenagel condensations. It is especially suitable for the dehalogenation, where it acts as the base of the elimination reaction and bonds the resulting hydrogen halide to form a pyridinium salt.
Dosage and directions
Uses: Pyridine is used as a solvent in organic chemistry and in industrial practice It is used to make medicines, vitamins, food flavorings, pesticides, paints, dyes, rubber products, adhesives, and waterproofing for fabrics
Safety and SDS
Read the safety data sheet before handling. Wear suitable gloves and eye protection.
View safety data sheet
| Product Name | PYRIDINE |
| Part Number | RXSOL-19-6605-002 |
Company Details:
RX MARINE INTERNATIONAL
105, A wing , BSEL , TECH PARK.
VASHI ,NEW BOMBAY 400703 INDIA
Branch : Kandla, Mumbai , Chennai, Vizag, Kolkata, UAE , OMAN , CANADA and KENYA
| Phone | +91 22 20871200 - 1400 |
| Fax | +91 22 27612100 :::AOH :0091 9821214367 |
| rxsolchemicals@gmail.com | |
| Website | www.rxmraine.com |
Substances
| Formula | C5H5N |
| Molecular weight | 79,10 g/mol |
| CAS-No. | 110-86-1 |
| EC-No. | 203-809-9 |
| Index-No. | 613-002-00-7 |
| Component | Classification | Concentration |
| Pyridine | ||
|
CAS-No. 110-86-1
EC-No. 203-809-9
Index-No. 613-002-00-7
|
Flam. Liq. 2; Acute Tox. 4;
Skin Irrit. 2; Eye Irrit. 2;
H225, H302, H332, H312,
H315, H319
|
<= 100 % |
Classification of the substance or mixture
| Flammable liquids, (Category 2) |
H225: Highly flammable liquid and vapor.
|
| Acute toxicity, (Category 4) | H302: Harmful if swallowed. |
| Acute toxicity, (Category 4) | H332: Harmful if inhaled. |
| Acute toxicity, (Category 4) | H312: Harmful in contact with skin. |
| Skin irritation, (Category 2) | H315: Causes skin irritation. |
| Eye irritation, (Category 2) | H319: Causes serious eye irritation. |
Label elements
| Signal Word | Danger |
| Hazard Statements |
H225 Highly flammable liquid and vapor.
H302 + H312 + H332 Harmful if swallowed, in contact with skin or if inhaled.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
|
| Precautionary Statements |
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.
P301 + P312 IF SWALLOWED: Call a POISON CENTER/ doctor if you feel unwell.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER/ doctor if you feel unwell.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
|
| Supplemental Hazard Statements | None |
| Reduced Labeling (<= 125 ml) | |
| Signal Word | Danger |
| Hazard statement | None |
| Precautionary statement | None |
| Supplemental Hazard Statements | None |
| Other hazards |
This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.
Ecological information:
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Toxicological information:
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher. Lachrymator., Stench.
|
| General Advice | Show this material safety data sheet to the doctor in attendance. |
| If inhaled | After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration. Oxygen if necessary. Immediately call in physician. |
| In case of skin contact | In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician. |
| In case of eye contact | After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses. |
| If swallowed | After swallowing: immediately make victim drink water (two glasses at most). Consult a physician. |
| Most important symptoms and effects, both acute and delayed | The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 |
| Indication of any immediate medical attention and special treatment needed | No data available |
| Suitable extinguishing media | Small (incipient) fires must be extinguished with alcohol resistant foam, dry chemical powder or carbon dioxide. Large amounts of water are ineffective. Cool containers with large amounts of water. |
| Special hazards arising from the substance or mixture |
Carbon oxides
Nitrogen oxides (NOx)
Combustible.
Pay attention to flashback.
Vapors are heavier than air and may spread along floors.
Development of hazardous combustion gases or vapours possible in the event of fire.
Forms explosive mixtures with air at ambient temperatures.
|
| Advice for firefighters | Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing. |
| Further information | Remove container from danger zone and cool with water. Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system. |
| Personal precautions, protective equipment and emergency procedures |
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition. Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.
|
| Environmental precautions | Do not let product enter drains. Risk of explosion. |
| Methods and material for containment and cleaning up | Large spills should be collected mechanically (remove by pumping) for disposal. Ventilate the area.Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ). Dispose of properly. Clean up affected area. |
| Reference to other sections | For disposal see section 13. |
Precautions for safe handling
| Advice on safe handling | Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols. |
| Advice on protection against fire and explosion | Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge. |
| Hygiene measures | Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance. For precautions see section 2.2. |
| Conditions for safe storage, including any incompatibilities | |
| Storage conditions |
Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.
Handle and store under inert gas.
|
| Storage class | Storage class (TRGS 510): 3: Flammable liquids |
| Specific end use(s) | Apart from the uses mentioned in section 1.2 no other specific uses are stipulated |
Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
| Application Area | Routes of exposure | Health effect | Value |
| Worker DNEL, longterm | inhalation | Systemic effects | 2,5 mg/m3 |
| Worker DNEL, acute | inhalation | Systemic effects | 7,5 mg/m3 |
| Worker DNEL, longterm |
dermal
|
Systemic effects | |
| Worker DNEL, acute |
dermal
|
Systemic effects | |
| Consumer DNEL, longterm | inhalation | Systemic effects | 0,6 mg/m3 |
| Consumer DNEL, longterm | dermal | Systemic effects | |
| Consumer DNEL, longterm | oral | Systemic effects |
Predicted No Effect Concentration (PNEC)
| Compartment | Value |
| Fresh water | 0,3 mg/l |
| Sea water | 0,03 mg/l |
| Aquatic intermittent release |
3 mg/l
|
| Sediment |
3,2 mg/kg
|
| Sea sediment | 0,32 mg/kg |
| Sewage treatment plant | 2 mg/l |
| Soil | 0,46 mg/kg |
Exposure controls
Personal protective equipment
| Eye/face protection | Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses |
| Skin protection |
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: butyl-rubber
Minimum layer thickness: 0,7 mm
Break through time: 240 min
Material tested:Butoject® (KCL 898)
|
| Body Protection |
Flame retardant antistatic protective clothing.
|
| Respiratory protection |
Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic
compounds
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.
|
| Control of environmental exposure | Do not let product enter drains. Risk of explosion. |
| Physical state | Liquid |
| Color | Colorless |
| Odor | Pungent |
| Melting point/freezing point | Melting point/range: -42 °C - lit. |
| Initial boiling point and boiling range | 115 °C - lit. |
| Flammability (solid, gas) | No data available |
| Upper/lower flammability or explosive limits |
Upper explosion limit: 12,4 %(V)
Lower explosion limit: 1,8 %(V)
|
| Flash point | 20 °C - closed cup - ISO 1523 |
| Autoignition temperature |
900 °C
at 1.013 hPa
|
| Decomposition temperature | ca. 490 °C |
| pH | ca.8,81 at 20 °C |
| Viscosity |
Viscosity, kinematic: No data available
Viscosity, dynamic: ca.0,88 mPa.s at 25 °C
|
| Water solubility | ca.1.000 g/l at 20 °C soluble |
| Partition coefficient: n-octanol/water | log Pow: ca.0,64 at 20 °C - (Lit.), Bioaccumulation is not expected. |
| Vapor pressure | ca.26,7 hPa at 25 °C |
| Density | 0,978 g/cm3 at 25 °C - lit. |
| Relative density | No data available |
| Relative vapor density | No data available |
| Particle characteristics | No data available |
| Explosive properties | No data available |
| Oxidizing properties | None |
| Other safety information | |
| Solubility in other solvents |
Diethyl ether at 20 °C
- miscible
Ethanol at 20 °C
- miscible
|
| Surface tension | 36,56 mN/m at 25 °C |
| Dissociation constant | 5,25 at 25 °C |
| Relative vapor density | 2,73 |
| Reactivity |
Vapors may form explosive mixture with air.
|
| Chemical stability | The product is chemically stable under standard ambient conditions (room temperature) |
| Possibility of hazardous reactions |
Risk of explosion with:
perchloric acid
nitrogen oxides
halogen-halogen compounds
Risk of ignition or formation of inflammable gases or vapours with:
chlorosulfonic acid
chromium(VI) oxide
Acid anhydrides
fuming sulfuric acid
Oxidizing agents
perchromates
Nitric acid
nitrogen dioxide
Exothermic reaction with:
Fluorine
sulfuric acid
silver perchlorate
|
| Conditions to avoid | Warming |
| Incompatible materials | Rubber, Various plastics,Various metals |
| Hazardous decomposition products | In the event of fire: see section 5 |
| Acute toxicity |
LD50 Oral - Rat - 1.500 mg/kg
Remarks: (ECHA)
Symptoms: Vomiting, Nausea
Acute toxicity estimate Oral - 1.500 mg/kg
(Calculation method)
LC50 Inhalation - Rat - male - 4 h - 17,1 mg/l - vapor
(US-EPA)
Symptoms: mucosal irritations, Cough, Shortness of breath
Acute toxicity estimate Inhalation - 17,1 mg/l - vapor
(Calculation method)
LD50 Dermal - Rabbit - > 1.000 - 2.000 mg/kg
(OECD Test Guideline 402)
Acute toxicity estimate Dermal - 1.000,1 mg/kg
(Calculation method)
|
| Skin corrosion/irritation |
Skin - Rabbit
Result: Mild skin irritation - 24 h
(Draize Test)
|
| Serious eye damage/eye irritation |
Eyes - Rabbit
Result: Irritating to eyes. - 24 h
Remarks: (ECHA)
|
| Respiratory or skin sensitization |
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
|
| Germ cell mutagenicity |
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Test Type: Micronucleus test
Species: Mouse
Cell type: Bone marrow
Application Route: Intraperitoneal injection
Method: OECD Test Guideline 475
Result: negative
|
| Carcinogenicity | No data available |
| Reproductive toxicity | No data available |
| Specific target organ toxicity - single exposure | No data available |
| Specific target organ toxicity - repeated exposure | No data available |
| Aspiration hazard | No data available |
| Additional Information | |
| Endocrine disrupting properties Product: | |
| Assessment |
The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male and female - Oral - 102 Weeks - NOAEL (No observed adverse effect level) - 7 mg/kg
RTECS: UR8400000
burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea, Vomiting, Dizziness, tachycardia, nervousness, insomnia, Skin disorders, loss of appetite
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Systemic effects:
After uptake:
Headache
In high doses:
narcosis
cardiovascular disorders
Circulatory collapse
Chronic uptake results in damage of:
Liver
Kidney
Good warning effect due to low odour threshold.
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
|
| Toxicity | |
| Toxity to fish |
Semi-static test EC50 - Danio rerio (zebra fish) - 560 - 1.000 mg/l -
96 h
(OECD Test Guideline 203)
Remarks: (in analogy to similar products)
|
|
Toxicity to daphnia
and other aquatic
invertebrates
|
EC50 - Daphnia magna (Water flea) - 320 mg/l - 48 h
(OECD Test Guideline 202)
Remarks: (in analogy to similar products)
|
| Toxicity to algae |
Static test EC50 - Pseudokirchneriella subcapitata - 320 mg/l - 72 h
(OECD Test Guideline 201)
Remarks: (in analogy to similar products)
|
| Persistence and degradability | |
| Biodegradability |
aerobic - Exposure time 28 d
Result: 97 % - Readily biodegradable.
(OECD Test Guideline 301B)
|
| Bioaccumulative potential | No data available |
| Mobility in soil | No data available |
| Results of PBT and vPvB assessment | This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher. |
| Endocrine disrupting properties Product | |
| Assessment | The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher |
| Other adverse effects | No data available |
| Waste Treatment Methods | No data available |
| UN number | ADR/RID: 1282 IMDG: 1282 IATA: 1282 |
| UN proper shipping name |
ADR/RID: PYRIDINE
IMDG: PYRIDINE
IATA: Pyridine
|
| Transport hazard class(es) | ADR/RID: 3 IMDG: 3 IATA: 3 (8) |
| Packaging group | ADR/RID: ll IMDG: ll IATA: ll |
| Environmental hazards | ADR/RID: no IMDG Marine pollutant: no IATA: no |
| Special precautions for user | |
| Tunnel restriction code | (D/E) |
| Further information | No data available |
| Safety, health and environmental regulations/legislation specific for the substance or mixture | This material safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006. |
|
National legislation
Seveso III: Directive 2012/18/EU of the
European Parliament and of the Council
on the control of major-accident hazards
involving dangerous substances.
|
P5c FLAMMABLE LIQUIDS |
| Other regulations |
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
|
| Chemical Safety Assessment | A Chemical Safety Assessment has been carried out for this substance. |
| Other Information |
The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and weassume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Rx Marine International has been advised of the possibility of such damages. DISCLAIMER OF LIABILITY :The information in this SDS was obtained from sources which we believe are reliable. However, the information is provided without any warranty, express or implied, regarding its correctness. The conditions or methods of handling, storage, use or disposal of the product are beyond our control and may be beyond our knowledge. For this and other reasons, we do not assume responsibility and expressly disclaim liability for loss, damage or expense arising out of or in any way connected with the handling, storage, use or disposal of the product. This MSDS was prepared and is to be used only for this product. If the product is used as a component in another product, this MSDS information may not be applicable. |
